HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxypyrrolidine → 4-(3-Hydroxypyrrolidin-1-yl)-pyridine-2-carboxylic acid phenylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Reactant | 4-Bromo-pyridine-2-carboxylic acid phenylamide | HCID 86695826 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 4-(3-Hydroxypyrrolidin-1-yl)-pyridine-2-carboxylic acid phenylamide | HCID 86695827 | 61.5% |
Reaction Steps
A solution of dl-3-pyrrolidinol (0.17 g, 1.95 mmol) and 4-bromo-pyridine-2-carboxylic acid phenylamide (0.36 g, 1.3 mmol) in 1-butanol (25 mL) was heated at 100° C. for 15 hours. The reaction was applied to silica gel (25 g) and eluted with chloroform then chloroform:methanol 9:1 to give the title compound 227 mg (0.80 mmol, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388176B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-31581ec3de1342589369d4e17ce65759 |
| Source note | uspto-grants-2016_07 |