2-(Methylthio)-5,6,7,8-tetrahydropyrido[4,3-D]pyrimidine → N-(3-isopropylphenyl)-3-methyl-5-[2-(methylthio)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]benzamide
Reaction equation
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:12][NH:11][CH2:10][CH2:9][C:7]=2[N:8]=1.Br[C:14]1[CH:15]=[C:16]([CH:29]=[C:30]([CH3:32])[CH:31]=1)[C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH:26]([CH3:28])[CH3:27])[CH:21]=1)=[O:18]>>[CH:26]([C:22]1[CH:21]=[C:20]([NH:19][C:17](=[O:18])[C:16]2[CH:15]=[C:14]([N:11]3[CH2:10][CH2:9][C:7]4[N:8]=[C:3]([S:2][CH3:1])[N:4]=[CH:5][C:6]=4[CH2:12]3)[CH:31]=[C:30]([CH3:32])[CH:29]=2)[CH:25]=[CH:24][CH:23]=1)([CH3:28])[CH3:27]Participants
3
Procedure
In a manner similar to that described for Example 138, 2-(methylsulfanyl)-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine and 3-bromo-N-(3-isopropylphenyl)-5-methylbenzamide were converted to the title compound.
Sources & evidence
- ORD record
- ord-56840269c35e41d7b8ae4d5faf0798c8
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09388176B2
Reaction notes
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