反应详情

温度

90 °C

To a solution of 1-(1H-indazol-3-yl)ethanone [4498-72-0](2 g, 12.46 mmol) in CH3CN (50 mL) was added K2CO3 (3.97 g, 28.7 mmol) and tert-butyl 2-bromoacetate (2.58 mL, 17.48 mmol). The reaction mixture was stirred at 90° C. overnight. The reaction mixture was filtered, the residue was washed with CH3CN and the filtrate was concentrated under vacuum. The material thus obtained was used directly in the next step without further purification. MS: 275 [M+H]+; tR (HPLC conditions d): 3.78 min.

1. filtrationThe reaction mixture was filtered
2. washthe residue was washed with CH3CN
3. concentrationthe filtrate was concentrated under vacuum
4. customThe material thus obtained
5. customwas used directly in the next step without further purification
6. custom3.78 min.