Trifluoroacetic acid → 1386457-64-2

HRID 1052105Notes

Reaction equation

HRID 1052105 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[NH2:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283122Tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate

Product 1

HCID 682833421386457-64-2

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 2-(3-carbamoyl-1H-indazol-1-yl)acetate (3.42 g, 12.4 mmol) in CH2Cl2 (20 mL) was added TFA (10 mL, 130 mmol) and the resulting mixture was stirred at RT for 16 h. The reaction mixture was concentrated in vacuo, the residual solid was suspended in MeOH and concentrated again in vacuo to give the title compound. MS (LC/MS): 220 [M+H]+; tR (HPLC conditions d): 1.79 min.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. concentrationconcentrated again in vacuo

Sources & evidence

ORD record
ord-3c8f59bfd65f40498ef28df1629718b6
Source dataset
uspto-grants-2016_07
Patent number
US09388199B2

Reaction notes

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