Trifluoroacetic acid → 1H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-

Participants

Reaction Steps

To a solution of tert-butyl 2-(3-cyano-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate (663 mg, 2.40 mmol) in TFA (6 mL) was subjected to microwave irradiation at 140° C. for 90 min. The reaction mixture was concentrated in vacuo, the residual solid was suspended in MeOH and volatiles were removed again in vacuo. MS: 221.0 [M+H]+; tR (HPLC conditions d): 0.23 min.

Provenance & Evidence