Trifluoroacetic acid → HCID 68283471, compound

HRID 1052113Notes

Reaction equation

HRID 1052113 reaction equation
[C:1]([C:3]1[C:11]2[C:6](=[CH:7][N:8]=[C:9]([CH3:12])[CH:10]=2)[N:5]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:4]=1)#[N:2].C(O)(C(F)(F)F)=[O:22]>>[C:1]([C:3]1[C:11]2[C:6](=[CH:7][N:8]=[C:9]([CH3:12])[CH:10]=2)[N:5]([CH2:13][C:14]([OH:16])=[O:15])[N:4]=1)(=[O:22])[NH2:2]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68283337Tert-butyl 2-(3-cyano-5-methyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate

Product 1

HCID 68283471HCID 68283471, compound

Procedure

A solution of tert-butyl 2-(3-cyano-5-methyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate (250 mg, 0.92 mmol) in TFA (4 mL) was subjected to microwave irradiation at 140° C. for 90 min. The reaction mixture was concentrated in vacuo, the residual solid was suspended in MeOH and concentrated again in vacuo. MS: 235.0 [M+H]+; tR (HPLC conditions d): 0.24 min.

Workup

  1. customirradiation at 140° C. for 90 min
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. concentrationconcentrated again in vacuo
  4. custom0.24 min.

Sources & evidence

ORD record
ord-b6c4de57bf674f94ac4e201294ea64a4
Source dataset
uspto-grants-2016_07
Patent number
US09388199B2

Reaction notes

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