Dimethylamine → 4-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)-N,N-dimethylpicolinamide

HRID 1052295Notes

Reaction equation

HRID 1052295 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][C:13]2[N:14]=[C:15]3[CH:21]=[C:20]([C:22]4[CH:27]=[CH:26][N:25]=[C:24]([C:28](O)=[O:29])[CH:23]=4)[NH:19][C:16]3=[N:17][CH:18]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[CH3:31][NH:32][CH3:33]>>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1)[CH2:11][CH2:12][C:13]1[N:14]=[C:15]2[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][N:25]=[C:24]([C:28]([N:32]([CH3:33])[CH3:31])=[O:29])[CH:23]=3)[NH:19][C:16]2=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 899635894-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)picolinic acid

Product 1

HCID 730583284-(2-(3,5-Dimethoxyphenethyl)-5H-pyrrolo[2,3-b]pyrazin-6-yl)-N,N-dimethylpicolinamide

Procedure

The compound was prepared by using procedures analogous to those described for the synthesis of Example 73, Step 3 starting from 4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3-b]pyrazin-6-yl}pyridine-2-carboxylic acid and N,N-dimethyl amine (2.0 M in THF). LCMS calculated for C24H26N5O3 (M+H)+: m/z=432.2. Found 432.2.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-7aa16fb2c7e54155bb289bb8b8ee1fbd
Source dataset
uspto-grants-2016_07
Patent number
US09388185B2

Reaction notes

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