Sodium Chloride → HCID 178511803, compound

HRID 1052340Notes

Reaction equation

HRID 1052340 reaction equation
[Cl-:1].[Cl-].[Ca+2:3].[NH2:4][C@H:5]([C:12]([OH:14])=[O:13])[CH2:6][C:7]1[N:11]=[CH:10][NH:9][CH:8]=1.[Na+:15].[Cl-]>>[Cl-:1].[Cl-:1].[Ca+2:3].[NH2:4][C@H:5]([C:12]([OH:14])=[O:13])[CH2:6][C:7]1[N:11]=[CH:10][NH:9][CH:8]=1.[Na+:15].[Cl-:1]

Participants

4

Reactant 3

HCID 5234Sodium ChlorideHCID 5284359Calcium ChlorideHCID 178419078HCID 178419078, compound

Product 1

HCID 178511803HCID 178511803, compound

Procedure

The performance of the release procedure, using 50 mM CaCl2, 50 mM histidine and 100 mM NaCl is not scale dependent. The FVIII recovery increases with more than 9 times for a batch size of 150 kg. In addition, the resulting FVIII solution could be further concentrated through a capture anion exchanger. The volume reduction factor over the capture step was 165 times and the process time was about 4 h.

Workup

  1. temperatureThe FVIII recovery increases with more than 9 times for a batch size of 150 kg
  2. concentrationIn addition, the resulting FVIII solution could be further concentrated through a capture anion exchanger

Sources & evidence

ORD record
ord-b1c53270d95f4364bc520886201d438c
Source dataset
uspto-grants-2016_07
Patent number
US09388402B2

Reaction notes

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