HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium fluoride → HCID 118433835, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Bromo-6-chloropyrimidin-4-amine | HCID 45789713 | — |
| Reactant | HCID 118433752 | HCID 118433752 | — |
| Product | HCID 118433835 | HCID 118433835 | 110.3% |
Reaction Steps
(S)-2-(1-Aminoethyl)-3-phenyl-5-(phenylthio)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (142 mg, 0.39 mmol) was treated with treated 5-bromo-6-chloropyrimidin-4-amine (245 mg, 1.18 mmol), cesium fluoride (178 mg, 1.17 mmol), N,N-diisopropylethylamine (341 μl, 1.96 mol) according to Preparation 13 to give 0.23 g (75% yield) of the title compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09388189B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-0e75391018d84ccc9ecb7fbcc2fee05e |
| Source note | uspto-grants-2016_07 |