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HRID1052392

反应详情

EQUATION

反应方程式

HRID 1052392 的结构方程式

REACTANTS

反应物

3
结构：Nc1ccccc1
HCID6115

Aniline

C6H7N

结构：[CH3][Al]([CH3])[CH3]
HCID16682925

Aluminum, trimethyl-

C3H9Al

结构：COC(=O)c1c(Br)ccn1NC(=O)[C@H](CCOCc1ccccc1)NC(=O)OC(C)(C)C
HCID86722060

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H](CCOCc1ccccc1)C(=O)Nn1ccc(Br)c1C(=O)Nc1ccccc1
HCID131736129

未命名化合物

收率 63.4%

PROCEDURE

实验过程

(S)-Methyl 1-(4-(benzyloxy)-2-((tert-butoxycarbonyl)amino)butanamido)-3-bromo-1H-pyrrole-2-carboxylate (1 g, 1.96 mmol) was treated with aniline (893 μl, 9.8 mmol) and trimethyl aluminium (2 M in toluene, 4.9 mL, 9.8 mmol) according to the method of Preparation 10a. The residue was purified using SP1® Purification System (0% to 30%, hexane-ethyl acetate) a to obtain 0.71 g (63% yield) of the title compound. Purity 100%.

WORKUP

后处理

  1. customThe residue was purified
  2. customSP1® Purification System (0% to 30%, hexane-ethyl acetate)