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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1052431Generated: November 3, 2026

Hydrochloric Acid → HCID 118433800, compound

https://huagongshe.com/reaction/1052431

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant1,4-DioxaneHCID 31275—
ReactantHCID 131736155HCID 131736155—
ProductHCID 118433800HCID 118433800139.3%

Reaction Steps

(S)-tert-Butyl (1-(5-(3-methoxybenzyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)carbamate (129 mg, 0.23 mmol) was treated with a solution of hydrochloric acid in dioxane (4M, 2 mL, 8 mmol) according to the method described in Preparation 1 to obtain 120 mg (99% yield) of the title compound as a hydrochloride salt that was used in the following step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09388189B2
Source datasetuspto-grants-2016_07
ORD IDord-fdf2cc94df8a4730aa46dcebabff359b
Source noteuspto-grants-2016_07