Hydrochloric Acid → HCID 118433800, compound

HRID 1052431Notes

Reaction equation

HRID 1052431 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:33]=[CH:34][CH:35]=1)[CH2:6][C:7]1[CH:8]=[CH:9][N:10]2[C:15]=1[C:14](=[O:16])[N:13]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:12]([C@@H:23]([NH:25]C(=O)OC(C)(C)C)[CH3:24])=[N:11]2.Cl.O1CCOCC1>>[NH2:25][C@H:23]([C:12]1[N:13]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:14](=[O:16])[C:15]2=[C:7]([CH2:6][C:5]3[CH:33]=[CH:34][CH:35]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:8]=[CH:9][N:10]2[N:11]=1)[CH3:24]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 131736155HCID 131736155, compound

Product 1

HCID 118433800HCID 118433800, compoundYield 139.3%

Procedure

(S)-tert-Butyl (1-(5-(3-methoxybenzyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)carbamate (129 mg, 0.23 mmol) was treated with a solution of hydrochloric acid in dioxane (4M, 2 mL, 8 mmol) according to the method described in Preparation 1 to obtain 120 mg (99% yield) of the title compound as a hydrochloride salt that was used in the following step without further purification.

Workup

  1. customdescribed in Preparation 1

Sources & evidence

ORD record
ord-fdf2cc94df8a4730aa46dcebabff359b
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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