3-Amino-5-bromopyridine → HCID 57843410, compound

HRID 1052472Notes

Reaction equation

HRID 1052472 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:8])[CH:5]=[N:6][CH:7]=1.[F:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=1[S:17](Cl)(=[O:19])=[O:18]>>[Br:1][C:2]1[CH:3]=[C:4]([NH:8][S:17]([C:11]2[CH:12]=[CH:13][C:14]([F:16])=[CH:15][C:10]=2[F:9])(=[O:19])=[O:18])[CH:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 8176813-Amino-5-bromopyridineHCID 27342732,4-Difluorobenzenesulfonyl Chloride

Product 1

HCID 57843410HCID 57843410, compoundYield 102.1%

Procedure

5-Bromopyridin-3-amine (500 mg, 2.89 mmol) was treated with 2,4-difluorobenzene-1-sulfonyl chloride (390 μl, 2.90 mmol) according to the method described in Preparation 15b to give 1.03 g (100% yield) of the title compound as an oil. Purity 74%.

Sources & evidence

ORD record
ord-74e52565e44544c8913f8d17fd336f2d
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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