Methanesulfonyl chloride → N-(3-Iodo-5-morpholinophenyl)methanesulfonamide

HRID 1052487Notes

Reaction equation

HRID 1052487 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:8]=1)[NH2:5].[CH3:15][S:16](Cl)(=[O:18])=[O:17]>>[I:1][C:2]1[CH:3]=[C:4]([NH:5][S:16]([CH3:15])(=[O:18])=[O:17])[CH:6]=[C:7]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[CH:8]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 901027553-Iodo-5-morpholinoaniline

Product 1

HCID 90102530N-(3-Iodo-5-morpholinophenyl)methanesulfonamideYield 105%

Procedure

3-Iodo-5-morpholinoaniline (279 mg, 0.76 mmol) was treated with methanesulfonyl chloride (82 μl, 1.06 mmol) according to the method described in Preparation 15b to give 305 mg (95% yield) of the title compound as an oil. Purity 90%.

Sources & evidence

ORD record
ord-609383405f7f4e80ba1c642cfa5e7e9c
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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