反应详情

5-Bromo-2-chloro-3-nitropyridine (1 g, 4.21 mmol) was dissolved in EtOH (5 ml) and a solution of sodium ethoxyde (21% m/v in EtOH, 1.5 ml, 4.63 mmol) was added dropwise. Once the addition was finished, the solvent was evaporated under reduced pressure and water was added tot the residue. The reaction mixture was extracted with dichloromethane (×3). The organic phase was dried over magnesium sulphate, filtered and the solvent evaporated under reduced pressure. The resulting crude (805 mg, 77% yield) was pure enough to perform the next synthetic step. Purity: 100%

1. additionOnce the addition
2. customthe solvent was evaporated under reduced pressure and water
3. additionwas added tot the residue
4. extractionThe reaction mixture was extracted with dichloromethane (×3)
5. dry with materialThe organic phase was dried over magnesium sulphate
6. filtrationfiltered
7. customthe solvent evaporated under reduced pressure