反应详情

(S)-2-(1-((5-Bromo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (0.25 g, 0.42 mmol) was treated with 3-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (0.26 g, 1.05 mmol), sodium carbonate (0.11 g, 1.05 mmol), 1,1′-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (0.10 g, 0.13 mmol) and 10.6 ml 1,2-dimethoxyethane and 2.4 ml water as a solvents according to the method described in Preparation 62. The residue was purified using SP1® Purification System (0% to 100% n-hexane-ethyl acetate) to obtain 0.15 g (54% yield) of the title compound.

1. customdescribed in Preparation 62
2. customThe residue was purified
3. customSP1® Purification System (0% to 100% n-hexane-ethyl acetate)