Hydrazine hydrate (1:1) → HCID 90102692, compound

HRID 1052628Notes

Reaction equation

HRID 1052628 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([OH:12])[CH:11]=1)[C:5](OC)=[O:6].O.[NH2:14][NH2:15]>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([OH:12])[CH:11]=1)[C:5]([NH:14][NH2:15])=[O:6]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 53216607Methyl 3-bromo-5-hydroxybenzoate

Product 1

HCID 90102692HCID 90102692, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Methyl 3-bromo-5-hydroxybenzoate (1 g, 4.33 mmol) was treated with hydrazine hydrate (1 ml, 20.5 mmol) and acetonitrile (5 ml) as a solvent according the method described in Preparation 226a to obtain 0.8 g (64% yield) of the title compound that was used in the next synthetic step without further purification. Purity 80%.

Sources & evidence

ORD record
ord-362fd8a810514d6cabcacf4f8624fbe5
Source dataset
uspto-grants-2016_07
Patent number
US09388189B2

Reaction notes

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