反应详情

(S)-4-Methoxy-N-(3-(4-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)benzenesulfonamide (25 mg, 0.02 mmol) was treated with trifluoroacetic acid (500 μl, 6.49 mmol) and a solution of ammonia (7N in methanol, 500 μl, 3.50 mmol) according to the method described in Example 27. The residue was purified using SP1® Purification System (0% to 100% n-hexane-ethyl acetate) to obtain 13 mg (86% yield) of the title compound.

1. customThe residue was purified
2. customSP1® Purification System (0% to 100% n-hexane-ethyl acetate)