反应详情

25 gms of Aluminium chloride was added to 50 ml of dichloromethane and 4.5 ml of fluorobenzene. To this a solution of 50 ml of dichloromethane containing 10 gms of glutaric anhydride and 4.5 ml of fluorobenzene was added. Reaction mass was stirred at room temperature. After completion of reaction, reaction mass was quenched with ice & HCl solution at 0-10° C. Filtered the reaction mass. The obtained wet solid was dissolved in aq NaHCO3 solution at 60-70° C. and insoluable material was filtered. Cooled the filtrate and adjust pH to 2.0 by adding hydrochloric acid. Obtained solid was filtered and dried at 60-70° C. under vacuum to get 10 gm of 5-(4-Fluoro-phenyl)-5-oxo-pentanoic acid.

1. customReaction mass
2. customAfter completion of reaction, reaction mass
3. customwas quenched with ice & HCl solution at 0-10° C
4. filtrationFiltered the reaction mass
5. dissolutionThe obtained wet solid was dissolved in aq NaHCO3 solution at 60-70° C.
6. filtrationinsoluable material was filtered
7. temperatureCooled the filtrate
8. additionby adding hydrochloric acid
9. customObtained solid
10. filtrationwas filtered
11. customdried at 60-70° C. under vacuum