反应详情

10 gms of 5-Benzyloxy-5-(4-fluoro-phenyl)-1-morpholin-4-yl-pentan-1-one was added to 100 ml of isopropyl alcohol and 7.5 gms of potassium hydroxide. Heated the reaction mass at reflux temperature and maintain for about 36 hours and distilled off solvent completely. To the obtained oily mass 60 ml of water was added and washed with dichloromethane. Layers were separated and acidify the aqueous layer with hydrochloric acid and adjusted the pH to 2.0. The obtained aqueous layer was extracted with dichloromethane and dried the organic layer over sodium sulphate followed by concentration. 6.5 gms of 5-Benzyloxy-5-(4-fluoro-phenyl)-pentanoic acid was isolated in heptane.

1. temperatureHeated the reaction mass
2. temperatureat reflux temperature
3. temperaturemaintain for about 36 hours
4. distillationdistilled off solvent completely
5. additionTo the obtained oily mass 60 ml of water was added
6. washwashed with dichloromethane
7. customLayers were separated
8. extractionThe obtained aqueous layer was extracted with dichloromethane
9. dry with materialdried the organic layer over sodium sulphate
10. concentrationfollowed by concentration