Hydrochloric Acid → HCID 90273387, compound

HRID 1053109Notes

Reaction equation

HRID 1053109 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[O:15][C:16]([C:19]3[C:20]([NH2:32])=[N:21][CH:22]=[C:23]([C:25]4[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=4)[CH:24]=3)=[N:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(Cl)Cl.C(OCC)C>[NH:8]1[CH2:13][CH2:12][CH:11]([C:14]2[O:15][C:16]([C:19]3[C:20]([NH2:32])=[N:21][CH:22]=[C:23]([C:25]4[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][CH:26]=4)[CH:24]=3)=[N:17][N:18]=2)[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90273376HCID 90273376, compound

Product 1

HCID 90273387HCID 90273387, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-[5-(2-amino-5-p-tolyl-pyridin-3-yl)-[1,3,4]oxadiazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (250 mg, 0.574 mmol) in DCM (20 mL) was added 2M HCl in diethyl ether (20 mL) at 0° C. The reaction mixture was allowed to warm to ambient temperature, and was stirred for 2 h. After completion of the reaction, reaction mixture was filtered and washed with diethyl ether (2×30 mL), which afforded the title compound as a yellow solid.

Workup

  1. customAfter completion of the reaction, reaction mixture
  2. filtrationwas filtered
  3. washwashed with diethyl ether (2×30 mL), which

Sources & evidence

ORD record
ord-1fdb270e3c4c48f7b7b8b84f259cfd7e
Source dataset
uspto-grants-2016_07
Patent number
US09393248B1

Reaction notes

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