Tetrahydrofuran → 4-[5-(4-Chlorophenyl)-4-methyl-2-(1-oxopropyl)-3-thienyl]benzenesulfonamide

Temperature

72.5 °C

To a stirred solution of 5-(4-chlorophenyl)-3-(4-(N-((dimethylamino)methylene)sulfamoyl)phenyl)-N-methoxy-N,4-dimethylthiophene-2-carboxamide (compound 1d, 2.3 g, 4.55 mmol) in anhydrous THF (40 ml) at 25° C., Grignard reagent (ethyl magnesium bromide, 3.04 g, 22.8 ml, 22.77 mmol) was added dropwise and the reaction mixture was heated at 70-75° C. for 1 hr. The progress of the reaction was monitored by TLC. After cooling the reaction mixture to 0° C., the reaction mixture was quenched by adding a solution of saturated ammonium chloride (40 ml) and the resulting mixture was extracted with ethyl acetate (3×50 ml). The combined organic layer was dried over anhydrous Na2SO4. The solvent was evaporated from the dried organic layer under reduced pressure to obtain a crude product; which was purified by column chromatography over silica gel (100-200 mesh) using 30-35% ethyl acetate in hexane as an eluent to obtain the title compound which was further purified by precipitation by dissolving 1.1 g of the compound in dichloromethane (10 ml) and precipitating it by slow addition of diisopropyl ether. (0.89 g, 47%)

1. temperatureAfter cooling the reaction mixture to 0° C.
2. customthe reaction mixture was quenched
3. additionby adding a solution of saturated ammonium chloride (40 ml)
4. extractionthe resulting mixture was extracted with ethyl acetate (3×50 ml)
5. dry with materialThe combined organic layer was dried over anhydrous Na2SO4
6. customThe solvent was evaporated from the dried organic layer under reduced pressure
7. customto obtain a crude product
8. customwhich was purified by column chromatography over silica gel (100-200 mesh)

ORD record

ord-0e0b17e9ed084e87b021395de6e9189b

Source dataset

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09393247B2