HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Phenyl pyrrolidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-tert-Butyl 2-phenyl pyrrolidine-1,2-dicarboxylate | HCID 11335289 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Phenyl pyrrolidine-2-carboxylate | HCID 15598566 | — |
Reaction Steps
Compound 22 (500 mg, 1.71 mmol) was dissolved in dry DCM (6 mL). Trifluoroacetic acid (0.66 mL, 8.58 mmol) was then added to the solution at 0° C. and stirred under nitrogen for 1 h. The reaction mixture was then concentrated under vacuum and used directly in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09393306B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-4be3effd17b2422eaa653e35b4a42271 |
| Source note | uspto-grants-2016_07 |