Trifluoroacetic acid → Phenyl pyrrolidine-2-carboxylate

HRID 1053520Notes

Reaction equation

HRID 1053520 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:7].FC(F)(F)C(O)=O>C(Cl)Cl>[NH:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:7]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 113352891-tert-Butyl 2-phenyl pyrrolidine-1,2-dicarboxylate

Product 1

HCID 15598566Phenyl pyrrolidine-2-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 22 (500 mg, 1.71 mmol) was dissolved in dry DCM (6 mL). Trifluoroacetic acid (0.66 mL, 8.58 mmol) was then added to the solution at 0° C. and stirred under nitrogen for 1 h. The reaction mixture was then concentrated under vacuum and used directly in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was then concentrated under vacuum
  2. customused directly in the next step without further purification

Sources & evidence

ORD record
ord-4be3effd17b2422eaa653e35b4a42271
Source dataset
uspto-grants-2016_07
Patent number
US09393306B2

Reaction notes

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