HRID1053773

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID579813

3,4-Diethoxyphenylacetic acid

C12H16O4

结构：CN(C)C(=O)CN(C(=O)OC(C)(C)C)[C@H]1CCc2c(C(=N)NO)cccc21

HCID178484623

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(Cc2nc(-c3cccc4c3CC[C@@H]4N(CC(=O)N(C)C)C(=O)OC(C)(C)C)no2)cc1OCC

HCID67197972

未命名化合物

PROCEDURE

实验过程

(S)-tert-butyl (4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)(2-(dimethylamino)-2-oxoethyl)carbamate INT-64 was prepared using General Procedure 2, analogously to INT-63, from (S)-tert-butyl (2-(dimethylamino)-2-oxoethyl)(4-(N-hydroxycarbamimidoyl)-2,3-dihydro-1H-inden-1-yl)carbamate INT-62 and 2-(3,4-diethoxyphenyl)acetic acid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2731adfbe435485694836b40fd8a6a1f
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09394264B2
来源说明: uspto-grants-2016_07

反应 SMILES

[CH3:1][N:2]([CH3:27])[C:3](=[O:26])[CH2:4][N:5]([C@@H:13]1[C:21]2[C:16](=[C:17]([C:22](=[NH:25])[NH:23][OH:24])[CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14]1)[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].[CH2:28]([O:30][C:31]1[CH:32]=[C:33]([CH2:40][C:41](O)=O)[CH:34]=[CH:35][C:36]=1[O:37][CH2:38][CH3:39])[CH3:29]>>[CH2:28]([O:30][C:31]1[CH:32]=[C:33]([CH:34]=[CH:35][C:36]=1[O:37][CH2:38][CH3:39])[CH2:40][C:41]1[O:24][N:23]=[C:22]([C:17]2[CH:18]=[CH:19][CH:20]=[C:21]3[C:16]=2[CH2:15][CH2:14][C@@H:13]3[N:5]([CH2:4][C:3]([N:2]([CH3:1])[CH3:27])=[O:26])[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[N:25]=1)[CH3:29]