HRID1053838

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)Nc1ccc(-c2cnc([C@@H]3C[C@H](C4CCN(S(C)(=O)=O)CC4)CN3)[nH]2)cc1.Cl

HCID131736307

未命名化合物

HCID135741236

未命名化合物

PRODUCTS

生成物

结构：COC(=O)Nc1ccc(-c2cnc([C@@H]3C[C@H](C4CCN(S(C)(=O)=O)CC4)CN3C(=O)c3ccc(C(=N)NC(=O)OC(C)(C)C)cc3)[nH]2)cc1

HCID154052196

未命名化合物

PROCEDURE

实验过程

The compound prepared in Example 66 was treated with the compound prepared in Example 18 following the procedure described in Example 8 to give the title compound as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-af6e73495afd44eab9b46adae75e99f7
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09394250B2
来源说明: uspto-grants-2016_07

反应 SMILES

Cl.[CH3:2][S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C@@H:12]2[CH2:16][NH:15][C@H:14]([C:17]3[NH:18][C:19]([C:22]4[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:32])[O:30][CH3:31])=[CH:24][CH:23]=4)=[CH:20][N:21]=3)[CH2:13]2)[CH2:8][CH2:7]1)(=[O:5])=[O:4].[CH3:33][C:34]([O:37][C:38]([NH:40][C:41]([C:43]1[CH:51]=[CH:50][C:46]([C:47](O)=[O:48])=[CH:45][CH:44]=1)=[NH:42])=[O:39])([CH3:36])[CH3:35]>>[NH:42]=[C:41]([NH:40][C:38](=[O:39])[O:37][C:34]([CH3:35])([CH3:33])[CH3:36])[C:43]1[CH:44]=[CH:45][C:46]([C:47]([N:15]2[CH2:16][C@@H:12]([CH:9]3[CH2:8][CH2:7][N:6]([S:3]([CH3:2])(=[O:4])=[O:5])[CH2:11][CH2:10]3)[CH2:13][C@H:14]2[C:17]2[NH:18][C:19]([C:22]3[CH:23]=[CH:24][C:25]([NH:28][C:29]([O:30][CH3:31])=[O:32])=[CH:26][CH:27]=3)=[CH:20][N:21]=2)=[O:48])=[CH:50][CH:51]=1