methyl [4-(2-{(2S,4R)-4-[1-(methylsulfonyl)-4-piperidinyl]-2-pyrrolidinyl}-1H-imidazol-5-yl)phenyl]carbamate hydrochloride → tert-butyl N-[4-[(2S,4R)-2-[5-[4-(methoxycarbonylamino)phenyl]-1H-imidazol-2-yl]-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidine-1-carbonyl]benzenecarboximidoyl]carbamate

Participants

Role	Name	HCID	Charge
Reactant	methyl [4-(2-{(2S,4R)-4-[1-(methylsulfonyl)-4-piperidinyl]-2-pyrrolidinyl}-1H-imidazol-5-yl)phenyl]carbamate hydrochloride	HCID 131736307	—
Reactant	HCID 135741236	HCID 135741236	—
Product	tert-butyl N-[4-[(2S,4R)-2-[5-[4-(methoxycarbonylamino)phenyl]-1H-imidazol-2-yl]-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidine-1-carbonyl]benzenecarboximidoyl]carbamate	HCID 154052196	—

Reaction Steps

The compound prepared in Example 66 was treated with the compound prepared in Example 18 following the procedure described in Example 8 to give the title compound as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09394250B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-af6e73495afd44eab9b46adae75e99f7
Source note	uspto-grants-2016_07