反应详情

The ester thus obtained was dissolved in a mixture of tetrahydrofuran (10 mL), methanol (10 mL) and dichloromethane (3 mL). 2 M sodium hydroxide (4.31 mL) was added and the mixture stirred at room temperature for 3 h. Further 2 M sodium hydroxide (4.31 mL) was added and the reaction stirred at room temperature for 16 h. The mixture was concentrated in vacuo, diluted with water and ethyl acetate added. The resultant emulsion was acidified with 1 M hydrochloric acid (pH=2-3) and extracted with ethyl acetate. The combined ethyl acetate phases were dried and concentrated to give the title compound (0.274 g) as a pale yellow solid.

1. stirringthe reaction stirred at room temperature for 16 h
2. concentrationThe mixture was concentrated in vacuo
3. additiondiluted with water and ethyl acetate
4. additionadded
5. extractionextracted with ethyl acetate
6. dry with materialThe combined ethyl acetate phases were dried
7. concentrationconcentrated