Dichloromethane → 1-(2-(4-aminopiperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one

HRID 105386Notes

Reaction equation

HRID 105386 reaction equation
[Cl:36][CH2:37][Cl:38].[F:1][c:2]1[cH:3][cH:4][c:5]2[n:6][cH:7][c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:18][CH2:19]3)[c:10]2[cH:11]1.[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[F:1][c:2]1[cH:3][cH:4][c:5]2[n:6][cH:7][c:8](=[O:28])[n:9]([CH2:12][CH2:13][N:14]3[CH2:15][CH2:16][CH:17]([NH2:20])[CH2:18][CH2:19]3)[c:10]2[cH:11]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59397942tert-butyl{1-[2-(7-fluoro-2-oxoquinoxalin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 593979071-(2-(4-aminopiperidin-1-yl)ethyl)-7-fluoroquinoxalin-2(1H)-one

Sources & evidence

ORD record
ord-02de07f1f7644895abc8571484eca957
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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