2-Chlorophenol → HCID 68919761, compound

HRID 1053878Notes

Reaction equation

HRID 1053878 reaction equation
[OH:1][C@@H:2]1[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1O>>[ClH:14].[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:1][C@H:2]1[CH2:6][CH2:5][NH:4][CH2:3]1

Participants

3

Reactant 2

HCID 72452-ChlorophenolHCID 6544479tert-Butyl (3R)-3-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 68919761HCID 68919761, compoundYield 54%

Procedure

The title compound was prepared from tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate and 2-chlorophenol, using the same method as that described for preparation 84, as a pale pink solid in 54% yield. LCMS APCI m/z 198 [M+H]+

Workup

  1. customthat described for preparation 84, as a pale pink solid in 54% yield

Sources & evidence

ORD record
ord-fbf39f2fb44444af8b06a93647895b2d
Source dataset
uspto-grants-2016_07
Patent number
US09394278B2

Reaction notes

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