Methyl iodide → HCID 86730302, compound

HRID 1053968Notes

Reaction equation

HRID 1053968 reaction equation
[O:1]=[C:2]1[CH2:6][S:5][CH2:4][CH:3]1[C:7]#[N:8].[C:9](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH3:9][C:3]1([C:7]#[N:8])[C:2](=[O:1])[CH2:6][S:5][CH2:4]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 3266764-Cyano-3-tetrahydrothiophenone

Product 1

HCID 86730302HCID 86730302, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
35 °C

Procedure

To a solution of 4-oxotetrahydrothiophene-3-carbonitrile (0.50 g, 3.9 mmol) in anhydrous acetone (7.8 mL) was added potassium carbonate (1.63 g, 11.8 mmol), followed by iodomethane (0.56 g, 3.9 mmol). The resulting mixture was stirred at 35° C. for 1 hour. The mixture was cooled to ambient temperature, filtered, and carefully concentrated in vacuo to afford the title compound. The residue was carried forward without further purification.

Workup

  1. temperatureThe mixture was cooled to ambient temperature
  2. filtrationfiltered
  3. concentrationcarefully concentrated in vacuo

Sources & evidence

ORD record
ord-b3d644c6aac24d5481bca73a54f57642
Source dataset
uspto-grants-2016_07
Patent number
US09394282B2

Reaction notes

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