反应详情

Synthesized using compound 64a (70 mg, 0.28 mmol), imidazole (76 mg, 1.12 mmol) and K2CO3 (195 mg, 1.41 mmol) in acetonitrile according to Method B. Crude product was purified by flash chromatography on silica-gel using ethyl acetate as eluent. After flash chromatography the product was recrystallized in ethyl acetate. Light yellow solid. Yield: 62 mg, 94%. 1H NMR (CDCl3, 500 MHz): δH (ppm)=5.17 (s, 2H), 6.94 (t, J=1.3 Hz, 1H), 7.15 (t, J=1.1 Hz, 1H), 7.47-7.54 (m, 3H), 7.61 (s, 1H), 8.41-8.46 (m, 2H), 8.63 (s, 2H); 13C NMR (CDCl3, 125 MHz): δC (ppm)=46.0, 118.8, 127.0, 128.2, 128.7, 130.7, 131.1, 136.8, 137.2, 156.2, 164.8; (ESI): m/z=236.92 [M+H]+.

1. customSynthesized
2. customCrude product was purified by flash chromatography on silica-gel
3. customAfter flash chromatography the product was recrystallized in ethyl acetate