Methanol → 2-(3-Fluorophenyl)-4-methylpyrimidine-5-carboxylic acid

HRID 105411Notes

Reaction equation

HRID 105411 reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7]([CH3:19])[n:8][c:9](-[c:12]2[cH:13][c:14]([F:18])[cH:15][cH:16][cH:17]2)[n:10][cH:11]1.[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[CH3:27][OH:28].[Na+:21].[OH-:20].[OH2:29]>>[O:3]=[C:4]([OH:5])[c:6]1[c:7]([CH3:19])[n:8][c:9](-[c:12]2[cH:13][c:14]([F:18])[cH:15][cH:16][cH:17]2)[n:10][cH:11]1

Participants

7

Reactant 6

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 8028TetrahydrofuranHCID 685575422-(3-Fluoro-phenyl)-4-methyl-pyrimidine-5-carboxylic acid ethyl ester

Product 1

HCID 617025872-(3-Fluorophenyl)-4-methylpyrimidine-5-carboxylic acid

Sources & evidence

ORD record
ord-2f7c63945c1c4b019349282ef7ba00e6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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