HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2E)-3-[5-chloro-2-(difluoromethoxy)phenyl]prop-2-enoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 66743816 | HCID 66743816 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2E)-3-[5-chloro-2-(difluoromethoxy)phenyl]prop-2-enoic acid | HCID 5933260 | — |
Reaction Steps
To a solution of (E)-tert-butyl 3-(5-chloro-2-(difluoromethoxy)phenyl)acrylate (458 mg, 1.503 mmol) in DCM (4.0 mL) was added TFA (2.0 mL, 26.0 mmol). After 1 h, the solvent was removed to give Intermediate 15 as a white solid. MS (ESI) m/z: 249.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394276B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-529de74d16294fec82ebea36dad80198 |
| Source note | uspto-grants-2016_07 |