反应详情

温度

42.5 °C

In a four neck round bottom flask, charged dichloromethane (3400 ml), 2-((2R)-2-Hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl)-1H-isoindole-1,3(2H)-dione (340 g) and N,N′-dicarbonyldiimidazole (209.13 g) at 25 to 30° C. The obtained reaction mass then stirred for 8 hr. at 25 to 30° C. Reaction mass is concentrated under reduced pressure to obtain residue. Added tetrahydrofuran (1700 ml) to residue. The obtained mixture is heated to 40 to 45° C. for 30 minutes followed by cooling to room temperature. Finally obtained solid is filtered off and washed by tetrahydrofuran(170 ml)

1. customThe obtained reaction mass
2. customat 25 to 30° C
3. customReaction mass
4. concentrationis concentrated under reduced pressure
5. customto obtain residue
6. temperatureby cooling to room temperature
7. filtrationFinally obtained solid is filtered off
8. washwashed by tetrahydrofuran(170 ml)