Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate → [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate | HCID 20079591 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol | HCID 20079604 | 56% |
반응 단계
To a stirring solution of ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (1.0 g, 4.44 mmol) in THF (10 ml) was added LiAlH4 (0.169 g, 4.44 mmol) at 0-10° C. and stirred for 1 h at RT. Reaction mixture was cooled and quenched with saturated sodium sulfate solution till precipitates observed. Precipitates obtained were filtered and filtrate was evaporated to get desired product in 56% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09394300B2 |
| 출처 데이터셋 | uspto-grants-2016_07 |
| ORD ID | ord-d0e96f6c79d24a58a222558e0a7838af |
| 출처 메모 | uspto-grants-2016_07 |