反应详情

To a stirring solution of ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (1.0 g, 4.44 mmol) in THF (10 ml) was added LiAlH4 (0.169 g, 4.44 mmol) at 0-10° C. and stirred for 1 h at RT. Reaction mixture was cooled and quenched with saturated sodium sulfate solution till precipitates observed. Precipitates obtained were filtered and filtrate was evaporated to get desired product in 56% yield.

1. customReaction mixture
2. temperaturewas cooled
3. customquenched with saturated sodium sulfate solution
4. customtill precipitates
5. customPrecipitates
6. customobtained
7. filtrationwere filtered
8. customfiltrate was evaporated