Ethyl 2-(hydroxyamino)benzoate → Ethyl 2-(((2-(trifluoromethyl)thiazol-4-yl)methoxy)amino)benzoate

HRID 1054228Notes

Reaction equation

HRID 1054228 reaction equation
[OH:1][NH:2][C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6].Br[CH2:15][C:16]1[N:17]=[C:18]([C:21]([F:24])([F:23])[F:22])[S:19][CH:20]=1>>[F:22][C:21]([F:24])([F:23])[C:18]1[S:19][CH:20]=[C:16]([CH2:15][O:1][NH:2][C:3]2[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=2[C:5]([O:7][CH2:8][CH3:9])=[O:6])[N:17]=1

Participants

3

Reactant 2

HCID 13571167Ethyl 2-(hydroxyamino)benzoateHCID 694413474-(Bromomethyl)-2-(trifluoromethyl)thiazole

Product 1

HCID 90258571Ethyl 2-(((2-(trifluoromethyl)thiazol-4-yl)methoxy)amino)benzoateYield 52%

Procedure

The titled compound was prepared using similar procedure as that of Example-1 (step-2) using ethyl 2-(hydroxyamino)benzoate and product of step 3 described above in 52% yield.

Sources & evidence

ORD record
ord-3c9f90db63f14355ab673b252a23c5b1
Source dataset
uspto-grants-2016_07
Patent number
US09394300B2

Reaction notes

Loading…