Hydrochloric Acid → 4-(1-Hydroxy-5-isoquinolyl)aminopiperidine hydrochloride

Participants

Reaction Conditions

Reaction Steps

Intermediate 84 (76.6 mg) was added with concentrated hydrochloric acid (1.5 ml) and stirred with heating at 85° C. for 7 hours. The reaction mixture was cooled to room temperature, and then the residue was added with ethanol (1 ml) and diethyl ether (2 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (55.5 mg) as white powdery solid.

Provenance & Evidence