反应详情

温度

85 °C

Intermediate 84 (76.6 mg) was added with concentrated hydrochloric acid (1.5 ml) and stirred with heating at 85° C. for 7 hours. The reaction mixture was cooled to room temperature, and then the residue was added with ethanol (1 ml) and diethyl ether (2 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (55.5 mg) as white powdery solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. customThe deposited precipitates
3. filtrationwere collected by filtration
4. washwashed with diethyl ether