Cyclopentylamine → HCID 59589689, compound

HRID 1054411Notes

Reaction equation

HRID 1054411 reaction equation
Br[C:2]1[N:7]2[N:8]=[C:9]([NH2:11])[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[CH:12]1([NH2:17])[CH2:16][CH2:15][CH2:14][CH2:13]1>CC(N(C)C)=O.O>[CH:12]1([NH:17][C:2]2[N:7]3[N:8]=[C:9]([NH2:11])[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 2906CyclopentylamineHCID 252159395-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine

Product 1

HCID 59589689HCID 59589689, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 31374DimethylacetamideSolvent

Conditions

Temperature
180 °C

Procedure

To a solution of 5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine (0.5 g, 2.35 mmol) in dimethylacetamide (2 mL), cyclopentylamine (2.3 mL, 23.5 mmol) was added and the solution was heated under microwave irradiation (180° C., 180 min). The resulting mixture was diluted with water and extracted into ethyl acetate. The organics were washed with water then brine, and dried over magnesium sulfate. The solid (0.5 g) was used without further purification. LCMS1: 2.84 min, 218 [M+1].

Workup

  1. extractionextracted into ethyl acetate
  2. washThe organics were washed with water
  3. dry with materialbrine, and dried over magnesium sulfate
  4. customThe solid (0.5 g) was used without further purification
  5. custom2.84 min, 218 [M+1]

Sources & evidence

ORD record
ord-e5dfec5ab4494da6977633d764bfd4f1
Source dataset
uspto-grants-2016_07
Patent number
US09394301B2

Reaction notes

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