Hydrochloric Acid → HCID 118590298, compound

Participants

Reaction Steps

To a solution of (S)—N—((R)-1-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide (30.0 g, 84 mmol) in Dioxane (60 ml) at 0° C. was added 4N solution of HCl in Dioxane (150 ml) and stirred the content for 16 h at room temperature. The solvent was evaporated completely and the crude was washed with diethyl ether to obtain title product 22.0 g (crude) as off white solid. MS m/z 252.05 (M+H).

Provenance & Evidence