Hydrochloric Acid → HCID 118590298, compound

HRID 1054459Notes

Reaction equation

HRID 1054459 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][CH:20]2[CH2:24][CH2:23][O:22][CH2:21]2)=[C:6]([C@H:8]([NH:12][S@](C(C)(C)C)=O)[CH2:9][CH:10]=[CH2:11])[CH:7]=1.[ClH:25]>O1CCOCC1>[ClH:25].[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][CH:20]2[CH2:24][CH2:23][O:22][CH2:21]2)=[C:6]([C@H:8]([NH2:12])[CH2:9][CH:10]=[CH2:11])[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118590516HCID 118590516, compound

Product 1

HCID 118590298HCID 118590298, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of (S)—N—((R)-1-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide (30.0 g, 84 mmol) in Dioxane (60 ml) at 0° C. was added 4N solution of HCl in Dioxane (150 ml) and stirred the content for 16 h at room temperature. The solvent was evaporated completely and the crude was washed with diethyl ether to obtain title product 22.0 g (crude) as off white solid. MS m/z 252.05 (M+H).

Workup

  1. customThe solvent was evaporated completely
  2. washthe crude was washed with diethyl ether

Sources & evidence

ORD record
ord-6e08087db4674e65b9d744ce2c3082e2
Source dataset
uspto-grants-2016_07
Patent number
US09394305B2

Reaction notes

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