反应详情

温度

120 °C

A mixture of 1-ethyl-5-(2-methylprop-1-enyl)-3-(pyrrolidin-1-yl)-1H-1,2,4-triazole (441 mg, 2.00 mmol, Eq: 1.00), osmium(VIII) oxide (382 mg, 382 μl, 60.1 μmol, Eq: 0.03), sodium periodate (1.71 g, 8.01 mmol, Eq: 4) and benzyltriethylammonium chloride (182 mg, 801 μmol, Eq: 0.4) in dioxane (21 ml) and water (6.3 ml) was stirred for 2 hours at 120° C. The mixture was diluted with ethyl acetate and washed with 2× water and brine. The organic layer was separated, dried over magnesium sulfate, filtrated and evaporated affording 2-Ethyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazole-3-carbaldehyde (268 mg/69.2%) as a dark green viscous oil. MS: m/e=195.4 (M+H+)

1. washwashed with 2× water and brine
2. customThe organic layer was separated
3. dry with materialdried over magnesium sulfate
4. filtrationfiltrated
5. customevaporated