1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazole-5-carbaldehyde → 6-Chloro-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyridine

Participants

Reaction Steps

The desired product was prepared in analogy to Example 1 g) from ((6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-yl)methyl)triphenylphosphonium chloride (170 mg, 366 μmol, Eq: 1.00) and 1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazole-5-carbaldehyde (66.0 mg, 366 μmol, Eq: 1.00). 110 mg (91%) of the desired product were obtained as a light yellow solid. MS: m/z=330.4 (M+H+)

Provenance & Evidence