HCID 90032734, compound → HCID 72704900, compound

HRID 1054974Notes

Reaction equation

HRID 1054974 reaction equation
[CH3:1][C:2]1[N:7]2[N:8]=[C:9](/[CH:11]=[CH:12]/[C:13]3[N:17]([CH3:18])[N:16]=[C:15]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:14]=3)[N:10]=[C:6]2[C:5]([CH3:24])=[C:4]([CH3:25])[N:3]=1>C(O)C.[Pd]>[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH2:11][CH2:12][C:13]3[N:17]([CH3:18])[N:16]=[C:15]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:14]=3)[N:10]=[C:6]2[C:5]([CH3:24])=[C:4]([CH3:25])[N:3]=1

Participants

4

Reactant 1

HCID 90032734HCID 90032734, compound

Product 1

HCID 72704900HCID 72704900, compoundYield 62.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

(E)-5,7,8-Trimethyl-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-c]pyrimidine (32 mg) and Pd/C (10 mg) were stirred in ethanol (0.4 ml) under hydrogen for 1 h. The mixture was filtered and concentrated to give the product (20 mg, 62.5%) as a white waxy solid. MS: m/z=341.4 (M+H+)

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b09f844228384a14bc5aa85bf13b36a7
Source dataset
uspto-grants-2016_07
Patent number
US09394311B2

Reaction notes

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