Diketene → HCID 53467780, compound
Reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][OH:6].[CH2:7]=[C:8]1[O:12][C:10](=[O:11])[CH2:9]1>O1CCCC1>[OH:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:1])[C:10](=[O:11])[CH2:9][C:8](=[O:12])[CH3:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
A solution of 20 g (0.23 mol) of 3-methylamino-1-propanol in 50 ml tetrahydrofuran was added dropwise to a solution of 18 g of diketene (0.21 mol) in 200 ml tetrahydrofuran −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 29.2 g (0.17 mol, 79% yield) of a colorless oil.
Workup
- customThe reaction mixture was evaporated
- customthe residue purified by column chromatography
Sources & evidence
- ORD record
- ord-025a2807cfc743cd8e3ca01cc9fec91b
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09394324B2
Reaction notes
Loading…