Piperidin-4-ol → HCID 86682309, compound

Participants

Reaction Steps

0.351 mol (49.6 ml) of 4-methyl-3-oxovaleric acid methyl ester and 0.369 mol (37.3 g) of 4-hydroxypiperidine were stirred for 6 h at 120° C. in a Dean-Stark apparatus. 12 ml of methanol were collected. Subsequently, the excess starting materials were distilled off for 3 h on a rotary evaporator (80° C. water bath, 2 mbar). 71 g of the title compound were obtained.

Provenance & Evidence