Piperidin-4-ol → HCID 86682309, compound

HRID 1055237Notes

Reaction equation

HRID 1055237 reaction equation
CO[C:3](=[O:10])[CH2:4][C:5](=[O:9])[CH:6]([CH3:8])[CH3:7].[OH:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[OH:11][CH:12]1[CH2:17][CH2:16][N:15]([C:3](=[O:10])[CH2:4][C:5](=[O:9])[CH:6]([CH3:7])[CH3:8])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 2759969Methyl 4-methyl-3-oxopentanoate

Product 1

HCID 86682309HCID 86682309, compoundYield 94.8%

Procedure

0.351 mol (49.6 ml) of 4-methyl-3-oxovaleric acid methyl ester and 0.369 mol (37.3 g) of 4-hydroxypiperidine were stirred for 6 h at 120° C. in a Dean-Stark apparatus. 12 ml of methanol were collected. Subsequently, the excess starting materials were distilled off for 3 h on a rotary evaporator (80° C. water bath, 2 mbar). 71 g of the title compound were obtained.

Workup

  1. custom12 ml of methanol were collected
  2. distillationSubsequently, the excess starting materials were distilled off for 3 h on a rotary evaporator (80° C. water bath, 2 mbar)

Sources & evidence

ORD record
ord-704d06b4c39b41488221220b47cca428
Source dataset
uspto-grants-2016_07
Patent number
US09394324B2

Reaction notes

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