2-(Methylamino)ethanol → HCID 86682310, compound

HRID 1055238Notes

Reaction equation

HRID 1055238 reaction equation
CO[C:3](=[O:10])[CH2:4][C:5](=[O:9])[CH:6]([CH3:8])[CH3:7].[CH3:11][NH:12][CH2:13][CH2:14][OH:15]>>[OH:15][CH2:14][CH2:13][N:12]([CH3:11])[C:3](=[O:10])[CH2:4][C:5](=[O:9])[CH:6]([CH3:7])[CH3:8]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 2759969Methyl 4-methyl-3-oxopentanoate

Product 1

HCID 86682310HCID 86682310, compoundYield 97.4%

Procedure

0.351 mol (50 ml) of 4-methyl-3-oxovaleric acid methyl ester and 0.369 mol (29.5 ml) 2-(methylamino)ethanol were stirred for 15 h at 120° C. in a Dean-Stark apparatus. 12 ml of methanol were collected. Subsequently, the excess starting materials 2 h were distilled off on a rotary evaporator (80° C. water bath, 1 mbar). There were obtained 64 g of the title compound.

Workup

  1. custom12 ml of methanol were collected
  2. distillationSubsequently, the excess starting materials 2 h were distilled off on a rotary evaporator (80° C. water bath, 1 mbar)

Sources & evidence

ORD record
ord-77739a3f95354e11be4104952dd6a6f3
Source dataset
uspto-grants-2016_07
Patent number
US09394324B2

Reaction notes

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